Advancements in the structural health monitoring (SHM) technology of composite materials are of paramount importance for early detection of critical damage. In this work, direct-write ultrasonic transducers (DWTs) were designed for the excitation and reception of selective ultrasonic guided waves and fabricated by spraying 25 μm thick piezoelectric poly(vinylidene fluoride-co-trifluoroethylene) (P(VDF-TRFE)) coating with a comb-shaped electrode on carbon fiber reinforced polymer (CFRP) plates. The characteristics and performance of the ultrasonic DWTs were benchmarked with the state-of-the-art devices, discrete lead zirconate titanate (PZT) ceramic transducers surface-mounted on the same CFRP plates. The DWTs exhibited improved Lamb wave mode excitation (A0 or S0 mode) relative to the discrete PZT transducers. Moreover, high signal-to-noise ratio was obtained by effectively cancelling other modes and enhancing the directivity with the periodic comb-shaped electrode design of the DWTs, despite the smaller signal amplitudes. The enhanced directivity overcompensates for lower amplitude attenuation, making DWT a good candidate for locally monitoring critical stress hot-spot regions in the CFRP structure prone to early damage initiation. Further, it is shown that pairing a DWT sensor with a discrete PZT actuator could further achieve balanced performance in both wave mode selection and signal amplitudes, making this combination really attractive for ultrasonic SHM.Conventional single photon emission computed tomography (SPECT) relies on mechanical collimation whose resolution and sensitivity are interdependent, the best performance a SPECT system can attain is only a compromise of these two equally desired properties. To simultaneously achieve high resolution and sensitivity, we propose to use sensitive detectors constructed in a multi-layer interspaced mosaic detectors (MATRICES) architecture to accomplish part of the collimation needed. We name this new approach self-collimation. We evaluate three self-collimating SPECT systems and report their imaging performance 1) A simulated human brain SPECT achieves 3.88% sensitivity, it clearly resolves 0.5-mm and 1.0-mm hot-rod patterns at noise-free and realistic count-levels, respectively; 2) a simulated mouse SPECT achieves 1.25% sensitivity, it clearly resolves 50-μm and 100-μm hot-rod patterns at noise-free and realistic count-levels, respectively; 3) a SPECT prototype achieves 0.14% sensitivity and clearly separates 0.3-mm-diameter point sources of which the center-to-center neighbor distance is also 0.3 mm. Simulated contrast phantom studies show excellent resolution and signal-to-noise performance. The unprecedented system performance demonstrated by these 3 SPECT scanners is a clear manifestation of the superiority of the self-collimating approach over conventional mechanical collimation. It represents a potential paradigm shift in SPECT technology development.In many diagnostic imaging settings, including positron emission tomography (PET), images are typically used for multiple tasks such as detecting disease and quantifying disease. Unlike conventional image reconstruction that optimizes a single objective, this work proposes a multi-objective optimization algorithm for PET image reconstruction to identify a set of images that are optimal for more than one task. This work is reliant on a genetic algorithm to evolve a set of solutions that satisfies two distinct objectives. In this paper, we defined the objectives as the commonly used Poisson log-likelihood function, typically reflective of quantitative accuracy, and a variant of the generalized scan-statistic model, to reflect detection performance. The genetic algorithm uses new mutation and crossover operations at each iteration. After each iteration, the child population is selected with non-dominated sorting to identify the set of solutions along the dominant front or fronts. After multiple iterations, these fronts approach a single non-dominated optimal front, defined as the set of PET images for which none the objective function values can be improved without reducing the opposing objective function. This method was applied to simulated 2D PET data of the heart and liver with hot features. We compared this approach to conventional, single-objective approaches for trading off performance maximum likelihood estimation with increasing explicit regularization and maximum a posteriori estimation with varying penalty strength. Results demonstrate that the proposed method generates solutions with comparable to improved objective function values compared to the conventional approaches for trading off performance amongst different tasks. In addition, this approach identifies a diverse set of solutions in the multi-objective function space which can be challenging to estimate with single-objective formulations.In this paper a statistical modeling, based on stochastic differential equations (SDEs), is proposed for retinal Optical Coherence Tomography (OCT) images. In this method, pixel intensities of image are considered as discrete realizations of a Levy stable process. https://www.selleckchem.com/ This process has independent increments and can be expressed as response of SDE to a white symmetric alpha stable (sαs) noise. Based on this assumption, applying appropriate differential operator makes intensities statistically independent. Mentioned white stable noise can be regenerated by applying fractional Laplacian operator to image intensities. In this way, we modeled OCT images as sαs distribution. We applied fractional Laplacian operator to image and fitted sαs to its histogram. Statistical tests were used to evaluate goodness of fit of stable distribution and its heavy tailed and stability characteristics. We used modeled sαs distribution as prior information in maximum a posteriori (MAP) estimator in order to reduce the speckle noise of OCT images. Such a statistically independent prior distribution simplified denoising optimization problem to a regularization algorithm with an adjustable shrinkage operator for each image. Alternating Direction Method of Multipliers (ADMM) algorithm was utilized to solve the denoising problem. We presented visual and quantitative evaluation results of the performance of this modeling and denoising methods for normal and abnormal images. Applying parameters of model in classification task as well as indicating effect of denoising in layer segmentation improvement illustrates that the proposed method describes OCT data more accurately than other models that do not remove statistical dependencies between pixel intensities. |